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Ongoing Projects:

1. Switching of TGFbeta signaling outcomes in normal and disease states (Collaborators: Peter Gray - Salk Insitute, Julia Tchou - UPenn)

3. Tissue regeneration and wound healing (Collaborators: Athanasia Panopoulos - Notre Dame, Peter Gray - Salk Insititute)

4. Biomarker identification in pancreatic cancer (Collaborators: Michael Bouvet - UCSD, Claremont BioSolutions)

5. Influence of the microenvironment on homeostasis and cancer progression (Collaborators: Joan Brugge - Harvard, Julia Tchou - UPenn, Ben Spike - Huntsman Cancer Center)

Trainees in our group will gain experience with the following techniques: Immunohistochemistry/Immunofluorescence, qPCR/RT-PCR, Site-Directed Mutagenesis, Cell Biology, Intravital Cancer Imaging, RNAi Techniques, Viral Gene Delivery, Confocal/TIRF/Epi Microscopy, Chick-CAM and Orthotopic Xenograft Tumor Models, Cell Proliferation/Migration/Cycle/Transformation Assays, Radio-Immunoassays of Ligand-Receptor Interactions, Luciferase-Response Assays, Phosphoprotein Analysis, Kinase Assays, iPSC/ESC Culturing and Characterization, Adipocyte/Neuronal Cell Differentiation, Bioinfomatics, TGF-beta Superfamily Signaling, Analysis of Stem Cell Properties in Cancer Cells, Primary Cell Isolation and Characterization from Normal and Tumor Tissue, Zebrafish Husbandry and Developmental Studies, and FACS